Drunkest Cities 100 cities ranked: America's Drunkest Cities. Overdose on almost any medicine, and it can go from balm to bomb in an instant. A couple glasses of wine each day? Liquid fix-it for your heart. A bottle before bed? You might end up like the folks in Fresno. Our statistical sobriety checkpoint shows that the inebriated people there have one of the highest death rates from alcoholic liver disease (per data from the Centers for Disease Control and Prevention). In fact, Fresno was near the top in every measure of dangerous drinking, including the body count caused by booze-fueled car crashes, the number of arrests made for driving under the influence, the number of people who admit to binge drinking in the last month, and the severity of DUI penalties. The top-10: 1. Fresno, CA 2. Reno, NV 3. Billings, MT 4. Riverside, CA 5. Austin, TX 6. St. Louis, MO 7. San Antonio, TX 8. Lubbock, TX 9. Tucson, AZ 10. Bakersfield, CA Of the 100 cities listed, the least drunk city is Boston, MA.